Arenaviral Nucleoproteins Suppress PACT-Induced Augmentation of RIG-I Function To Inhibit Type I Interferon Production

Viral inhibitions of PACT-induced RIG-I activation

Differential inhibition of type I interferon induction by arenavirus nucleoproteins.

We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World and New World antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV)...

Suppression of PACT - induced type I interferon production by 1 herpes simplex virus type 1 Us 11 protein

* To whom correspondence should be addressed: Department of Biochemistry, The 20 University of Hong Kong, 3/F Laboratory Block, Faculty of Medicine Building, 21 21 Sassoon Road, Pokfulam, Hong Kong. Phone: +852-2819-2812; Fax: +852-285522 1254; E-mail: [email protected] and [email protected]. 23 JVI Accepts, published online ahead of print on 25 September 2013 J. Virol. doi:10.1128/JVI.02564-13 Copyright...

SRSF1 Facilitates Cytosolic DNA-Induced Production of Type I Interferons Recognized by RIG-I

BACKGROUND Evidence has shown that psoriasis is closely associated with infection; however, the mechanism of this association remains unclear. In mammalian cells, viral or bacterial infection is accompanied by the release of cytosolic DNA, which in turn triggers the production of type-I interferons (IFNs). Type I IFNs and their associated genes are significantly upregulated in psoriatic lesions...

ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon.

The cytosolic pathogen sensor RIG-I is activated by RNAs with exposed 5'-triphosphate (5'-ppp) and terminal double-stranded structures, such as those that are generated during viral infection. RIG-I has been shown to translocate on dsRNA in an ATP-dependent manner. However, the precise role of the ATPase activity in RIG-I activation remains unclear. Using in vitro-transcribed Sendai virus defec...